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87 Therefore, they control the influx and efflux of chemotherapeutic drugs, modulating the intracellular drug concentration and therefore, determining the therapeutic efficacy and the success or failure of patient treatment
Seasonal considerations matter too
The specificity and effective in vivo concentrations of many natural products or small molecule agonists are debatable, with some effects possibly stemming from their broad-spectrum antioxidant capacity rather than genuine Nrf2-specific action
These compounds, when produced in larger quantities under stress, can lead to extensive damage of DNA, proteins, and plasma/organelle membranes in the cell (Olinski et al., 1992
