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The mechanism is the same as CJC-1295: stimulation of pituitary GH release, leading to increased IGF-1 and downstream effects on collagen-producing cells in the dermis

Here we present the results of STEMS, a prospective, therapeutic exploratory, non-randomized, open-label, single-dose-finding phase 1 clinical trial (NCT03269071, EudraCT 2016-002020-86), performed at San Raffaele Hospital in Milan, Italy, evaluating the feasibility, safety and tolerability of intrathecally transplanted human fetal NPCs ( hf NPCs) in 12 patients with PMS (with evidence of disease progression, Expanded Disability Status Scale 6.5, age 1855 years, disease duration 220 years, without any alternative approved therapy)

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Growth differentiation factor 5-induced mesenchymal stromal cells enhance tendon healing