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Tirzepatide titration: 2.5mg to 15mg Tirzepatide uses a six-step titration over approximately 20-24 weeks: Weeks 1-4: 2.5mg weekly Weeks 5-8: 5mg weekly Weeks 9-12: 7.5mg weekly Weeks 13-16: 10mg weekly Weeks 17-20: 12.5mg weekly Week 21 onward: 15mg weekly (maximum dose) Not everyone reaches 15mg

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the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science

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