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Over time, chronic exposure to heavy metals can build up in your tissues

I looked it up

Indeed the upregulation of NRF2 (nuclear factor, erythroid-derived 2-like 2 factor) has been observed in a wide array of tumors including breast, ovarian, prostate, skin, lung and pancreas [32,44]
It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid metabolism and amino acid metabolism
And any supplementation that they take besides glutaryl, it's not gonna raise the levels to high normal