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However, 5 of these 11 drugs did not significantly alter the total cell number, which might suppress senescence phenotypes, whereas 5 significantly reduced both senescent cell and total cell numbers (Fig

Therefore, once one population, in this case PC, disappear then the other cell population (Tfh) is promoted (138)

Tumor-intrinsic NRF2 signaling promotes immunoevasion The tumor immune microenvironment is a complex, heterogenous system responsive to many different factors including cytokines, chemokines, neurotrophic and morphogenic factors, and others which regulate the chemotaxis and activity of immune cells within tumors and draining lymph nodes

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