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Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products

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Extracellular lactate accumulation favors migration and metastasis and acts as a reservoir of energy for non-hypoxic and OXOPHOS cells ( From the above, it is clear that metabolic symbiosis between the three zones is necessary for holistic growth and proliferation of cancer cells, and lactate shunt is the key to this metabolic adaptation. Compared to energy production, tumor growth and proliferation regulation under graded oxygen tension are much more complex