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For instance, the use of erastin can reduce the efflux of the multidrug resistance protein ATP-binding cassette subfamily B member 1 (ABCB1), leading to increased accumulation of chemotherapeutic drugs within tumor cells, thereby reversing resistance to docetaxel and platinum-based drugs (Zhou et al., 2019)

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

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These systems share signals through the vagus nerve, which carries information from the body's organs to the brain regions (Jackson et al., 2019

Gastrointestinal Effects The most commonly reported adverse events in combination research are gastrointestinal, consistent with the mechanisms of both components