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Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model

Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3

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This was followed by a 35-day pharmacokinetic blood sampling and safety assessment period (i.e., 45 times the estimated cagrilintide t 1/2 ), with blood samples collected on days 8, 15, 22, 29 and 36

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