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Because cobalamin in normally absorbed from food through the gastrointestinal tract, chronic diseases that adversely affect the ability of the intestines to absorb nutrients (inflammatory bowel disease is an excellent example) can lead to cobalamin deficiency

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FOXO4-DRI causes nuclear exclusion of active p53 and induces apoptosis in senescent TM3 Leydig cells Immunofluorescent staining showed elevated levels of Ser15-phospho-p53 in the nucleus of senescent TM3 Leydig cells (Figure 5A)

A novel noncanonical signaling pathway for the mu-opioid receptor

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