cdk4 glutathione CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets MYC induces CDK4/6 inhibitors resistance

Steyger 2021a

Free Radic Biol Med 7(2):197203

doi:10.1016/j.juro.2008.03.044

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Superoxide anion radicals (O2 ) can cause injury directly and can be converted into more damaging oxidant species such as hydroxyl radical (OH ) and hypochlorous acid (HOCl).37 Of the two, OH has been demonstrated as the key reactive oxygen species to cause pulmonary edema during acute lung injury.38 Hypoxemia secondary to Adult Respiratory Distress Syndrome (ARDS) and pulmonary edema may occur during COVID-19 infection.39 Besides causing tissue injury, ROS can also activate the NF-kB pathway to amplify inflammation through upregulation of expression of multiple genes, such as IL-6, TNF-, and chemokines