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White blood cells also influence the early differentiation of bone and tendon progenitor cells, and specific PRF protocols can activate white blood cells (especially the monocytes and platelets in the leukocyte-rich matrix) to secrete endogenous growth signaling factors like BMP-2, BMP-7, FGF, VEGF, PDGF, TGF-Beta, and Thrombospondin, which are released locally over the next few days to weeks to accelerate and strengthen tissue repair, and these can further activate recruitment and differentiation of Mesenchymal Stem Cells (MSCs) as well as expression of several tissue remodeling genes

However, the most important advantage is the very safe profile of BPC (the lethal dose (LD1) could be not achieved) (Seiwerth et al., 2018), emphasized in terms of its physiological role (assessed using in situ hybridization and immunostaining for BPC 157 in the human gastrointestinal mucosa, lung bronchial epithelium, the epidermal layer of the skin, and kidney glomeruli) (Seiwerth et al., 2018)

It would be in a really small niche circuit, whereas now it is advertised and promoted, and companies are shouting about it, which I personally dont agree with

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Peptides are not appropriate for clients who are pregnant or breastfeeding, who have active malignancy or a recent cancer history (varies by peptide), or who have certain other medical conditions we'll screen for at your consultation