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It is derived from a natural protective compound found in human stomach secretions

The body tightly regulates B12 absorption through intrinsic factor, a protein produced in the stomach that binds to B12 and facilitates its uptake in the terminal ileum

This reduces the inflammatory burden on the central nervous system without requiring a compound to cross the blood-brain barrier itself

Nigericin was then added for a further 45 minutes prior to harvest of the cell culture supernatant for quantification of (A) IL-1 and (B) IL-18 by TR-FRET and ELISA respectively

Abstract 3046: Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth