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its reversal by N -acetylcysteine seems to have therapeutic benefit in mouse models and patients with SLE Abstract Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to immune system dysregulation, abnormal activation and processing of cell-death signals, autoantibody production and fatal comorbidities

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[DOI] [PubMed] [Google Scholar] 18.Ursin R

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The appearance of white hair is therefore caused by a decrease in melanin synthesis and a reduced distribution of this pigment within the hair fibers