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Peripheral blood mononuclear cells (PBMC) and leukemic THP-1 cell viability can be affected by aqueous root extracts of WS (0.050.4 mg/ml), which can also increase oxidant scavenging and caspase [99, 100] activities while decreasing levels of tumor necrosis factor-alpha (TNF-), interleukin (IL)10, and glutathione (GSH) [112]

Elevated insulin causes an increase of free serum IGF-1, nevertheless, as resistance to insulin progresses, the liver becomes insensitive to insulin-mediated suppression of IGFBP-1 [254, 256]

In the phase 1b combination study, concomitant administration was described as well tolerated, with a safety picture consistent with the individual components

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