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Description
In liver regeneration (LR) studies, after partial hepatectomy (PHx), HSCs exhibited high glycolytic metabolic flux and increased PFKFB3 expression in the liver and cells, and LR after PHx involved the activation of PFKFB3 in HSCs, as well as an increase in PFKFB3 to promote the production of the glycolysis product lactic acid, which promotes the proliferation of HSCs through the p38/ERK MAPK signaling pathway (76)

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Other agents exist which also cause damage by a range of processes

Cobanoglu U, Demir H, Duran M, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH, Jr, Goin-Kochel RP, Vaz FM, Beaudet AL