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Myocarditis, or inflammation of the heart, has multiple causes but a viral infection is the most common trigger

This protection is characterized by reduced production of ROS, H 2 O 2 , and nitric oxide (NO), as well as an increased expression of genes encoding enzymes involved in OS defense [77]

Arginase: a critical regulator of nitric oxide synthesis and vascular function

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This suggests that after H 2 O 2 induction, FOXO4 facilitated Leydig cell senescence while maintaining the viability of senescent cells by repressing their apoptotic response