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Efficacy of minocycline in patients with amyotrophic lateral sclerosis: A phase III randomised trial
And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon

Cancer Lett 2005;225:111-20
That translates to tens of millions of people worldwide living with a condition that is only partially understood, frequently dismissed in conventional medical settings, and for which there is currently no FDA-approved treatment

The study has found that SFRP4 is involved in ISO-induced cardiomyocyte mitochondrial damage, and using an SFRP4 inhibitor can alleviate mitochondrial dysfunction in the myocardium and HL-1 cells (195)
