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Description
Fourteen metabolites were screened in the feces, including M1: m/z795.5 (loss of C 5 H 8 O 4 from M0), M2: m/z 765.5 (loss of C 6 H 10 O 5 from M0), M3: m/z 633.5 (loss of C 6 H 10 O 5 from M1), M4: m/z 603.5 (loss of C 6 H 10 O 5 from M2), M5: m/z 471.5 (loss of C 17 H 28 O 14 from M0), M6: m/z 943.5 (hydroxylation, M0+O), M7: m/z 897.5 (loss of hydroxymethylene from M0), M8: m/z 913.5 (loss of methylene from M0), M9: m/z 957.5 (hydroxylation and methylation, M0+CH 2 O), M10: m/z945.5 (hydrolysis, M0+H 2 O), M11: m/z 971.5 (hydroxylation and ethylation, M0+C 2 H 5 O), M12: m/z 899.5 (decarbonylation, M0-CO), M13: m/z 911.5 (dehydroxylation, M0-O), M14: m/z 941.5 (methylation, M0+CH 2 )
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Results Spatial reference memory was tested in homozygous 3, 7 and 12 month-old Tg4-42 and aged-matched WT mice in the MWM
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