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tissue Microenviron

Knight A, Bryan J, Wilson C, Hodgson JM, Davis CR, Murphy KJ

The molecular gutliver signaling, we substantially revised the manuscript with detailed discussions of key pathways: TLR4/NF-B, MAPK signaling, tight junction regulation, microbial metabolite signaling (e.g., SCFAs), and cytokine cascades

It also directly combats oxidative stress during sperm development and optimizing glutathione replenishment can improve sperm quality (Adeoye et al, 2018)

The higher risk of bias could be due to the nature of the MRS reproducibility studies (N = 13), and the inclusion of older studies where recruitment of healthy subjects was not as standardized compared to more recent publications