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In this regard, our ExM approach can potentially be a cost-effective alternative that allows interrogation throughout the entire depth of an adult animal in one setting, with imaging experiments carried out on standard confocal microscopes that are already common to many laboratories

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Here, we examine the role of the lipid environment by reconstituting purified human HCN channels into lipid nanodiscs and measuring successive cAMP binding to single HCN channels using nanophotonic waveguides

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