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Cell 168 , 344361 (2017)
Peptide-targeted delivery of EVs or exosomes EVs or exosomes are endogenous nanoparticles secreted from cells into circulation

Importantly, while these factors are considered modifiable, they are influenced by social and structural drivers of health (see Figure 3 ) and may not always be addressed solely through individual behavior change

Once inside the central nervous system, research published in Open Exploration highlights that EGCg acts directly on hyperactive microglial cells, the primary drivers of neuroinflammation

These data suggested that pharmacological stimulation of the NRF2/ARE signalling could be a valuable lever to a new therapeutic approach in ALS [253, 254]
