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This suggests that contacts outside of the ligand-binding site contribute to its improved affinity in the presence of ENL and, indeed, our model revealed an extensive interfacial interaction between CRBN and ENL YEATS, with a buried solvent-accessible surface area of ~2,258 2 and a high degree of shape complementarity (0.64 out of 1) 52
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eIF2: eukaryotic initiation factor 2

a patient may present with multiple lesions, and constitutional symptoms may be more pronounced