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Your body may recognize these clumps as foreign invaders and mount an antibody response, which could reduce the effectiveness of tirzepatide not just now but in future doses as well

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doi: 10.1128/mBio.00102-10

Intervention trials indicate that combined probiotic and prebiotic supplementation can significantly decrease TPOAb and TgAb concentrations, improve gut barrier integrity, and restore microbial diversity in HT patients (Liu et al