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After fusion of the phagosome with the lysosome, a phagolysosome is formed, in which the captured material is degraded and destroyed by lysosomal enzymes and other mechanisms such as the production of reactive oxygen species [47,48,49]

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While clinical validation of this mechanistic advantage continues to evolve, the dual-inhibition profile positions Polmacoxib as a promising therapeutic option for managing osteoarthritis