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This is problematic because when agonists and antagonists are not specific or selective enough, they do not provide the basis for the univocal and unambiguous identification of particular receptors (Salomone and Waeber, 2011)

Goblet cells, secreting mucin, are abundant in this organ, especially in the upper eyelid

Front Pain Res (Lausanne) 2024;4 doi: 10.3389/fpain.2023.1350578

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Thus, further research is needed before this approach could be used clinically (143)