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statins, proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors, fibrates, along with other emerging approaches, including theranostics and cytokine-targeted drugs, the long-term management of atherosclerosis remains challenged with safety concerns 8,9,10,11

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In addition, some natural compounds including flavonoids like epigallocatechin-3-gallate (EGCG) in green tea and curcumin have also been found to have DNA demethylating properties (Yang T
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