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urticaria, laryngeal oedema, bronchospasm, hypotension) should not be prescribed beta-lactam agents including penicillins, cephalosporins, carbapenems or monobactams [10], [23]

Additionally, plasma samples from mice collected 1 and 6 h after collection presented a decrease in UA monomers from 77.2 to 65.7%, accompanied by an increase in phase II metabolites (30), indicating that UA progressively forms conjugated metabolites after entering the plasma

Inhibition of P38 MAPK Downregulates the Expression of IL-1 to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats

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Studies also demonstrated that berberine sensitizes drug-resistant breast cancer cells to doxorubicin by the modulation of the AMPK-HIF-1 -P-gp pathway [214]