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BSO-OxMal treatment-induced distinctly enhanced DNA damage as compared to oxaliplatin also in non-necrotic parts of the tumor (Fig
Depending on cellular state and stress cues, TP53 can promote ferroptosis by repressing SLC7A11 to limit cystine uptake and GSH synthesis, inducing spermidine/spermine N1-acetyltransferase 1 ( SAT1 ) to enhance ROS generation through polyamine catabolism, and upregulating glutaminase 2 ( GLS2 ) to increase -ketoglutarate production and mitochondrial ROS 154-156
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Growth hormone stimulates skeletal muscle protein synthesis and antagonizes insulin's antiproteolytic action in humans
