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Briefly, proteins were digested with trypsin, and the peptide mixture was further labeled using the iTRAQ reagent kit (AB SCIEX, Framingham, USA)

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In detail, the anti-tumor immune system can be divided into two major parts: innate immunity and adaptive immunity, whereas the immune cells in the TME are stratified as immunosuppressive cells and immunostimulatory cells, and the balance between them determines the occurrence and development of cancer

Adjustment of the dose may also be required to alleviate the side effects
