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The epidermis comprises multiple layers, such as the stratum corneum, the stratum granulosum, the stratum spinosum, and the basal stratum, each of which is composed of cells such as keratinocytes, pigment cells and melanocytes, Langerhans cells, mast cells, and Merkel cells

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C., Stepanians, M., & Hayward, B

For example, oleanolic acid acetate ( 34 ) exerted an anti-inflammatory effect via inhibiting IKK/ to reduce the production of embryonic alkaline phosphatase and pro-inflammatory cytokines, including MCP-1, IL-1, IL-8, VCAM-1, and ICAM-1 [152]