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Depending on the chosen target(s), the review analyzed more than 80 distinctive targets, which were used in previous NO-agents studies with triple regimen, and the particular effectiveness of the given NO-agent(s) (aggravation (mostly L-NAME), protection (mostly L-arginine), and no effect (either L-NAME alone or L-arginine alone, or both, or combination L-NAME + L-arginine) [97]

Providers should ensure that market demand and consumer interest are weighed against appropriate clinical evidence, patient-specific need, quality controls, and a documented risk-benefit analysis before clinical use

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