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In severe COVID-19, as a consequence of cell death and tissue damage, intracellular ferritin is released out of the cells, with excess ferritin accumulating in the body to form hyperferritinemia (Kell and Pretorius, 2014)
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Recombinant protein expression in Escherichia coli: advances and challenges

Karch, C

But some might feel pain at the injection site, mild diarrhea, or itching