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Depending on the type of pathophysiologic process, water and sodium may be lost in physiologic proportion or lost disparately, with each type producing a somewhat different clinical picture, designated as normotonic (mostly isonatremic), hypertonic (mostly hypernatremic), or hypotonic (always hyponatremic) dehydration

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When tissue is damaged, the body needs to move repair cells to the injury site rapidly

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[DOI] [PubMed] [Google Scholar] 123.Wiffen P.J., Wee B., Moore R.A