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Chiang GC, et al

The high-dose IV delivery ensures maximum absorption and immediate therapeutic benefits that cannot be achieved through oral supplementation alone

In hepatocyte-specific GCN5L1 KO mice, increased glutamine uptake, along with elevated glutaminase activity via enhanced glutaminase (GLS), synergistically promotes hepatic glutaminolysis

As an example, in a rat model of -synuclein induced ER stress, in the absence of re-establishment of ER homeostasis, ATF6 activates proapoptotic CHOP protein in DA-ergic neurons