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2020;48(D1):D445D453
The decreased malate/pyruvate and GSH levels with LbNOX expression strongly suggest a decreased cytoplasmic (free) [NADPH]/[NADP + ], while the large increase in pyruvate also strongly suggests that the pyruvate/lactate, a proxy for the cytoplasmic (free) [NAD + ]/[NADH], increased, which likely drove the lifespan extension in the females
In: Kesharwani P, Greish K, editors
Ataxia telangiectasia: a review
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