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By elucidating the critical roles of ROS homeostasis in cellular physiology and disease treatment, this review aims to advance the discovery of potential biomarkers as well as the development of novel therapeutic approaches based on ROS homeostasis.

DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (cancer and repetitive sequences-associated diseases) are regulated

These genes prompt cells to create their own antioxidants to reduce oxidative strss

Glutathione is an endogenous redox couple in animal cells and plays important roles in antioxidant defense and detoxification, although it is unknown if oral glutathione supplementation affects exercise-induced physiological changes

HFD exacerbates hepatic lipid accumulation by enhancing lipogenic gene expression