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1 Overview of Lynch syndrome and associated cancer risks Lynch syndrome (LS) is a hereditary condition that predisposes individuals to various malignancies, most notably colorectal cancer (CRC) and endometrial cancer (EC) (1)

As well as activating SIRT1, BBR is also able to decrease FOXO1 acetylation, triggering anti-apoptotic signaling pathways via Bcl-2 expression, and Bax and caspase-3 downregulation (Yu et al., 2016)

10.1039/d2tb02001g 38 Carvalho-SilvaJ

Odlaug BL, Grant JE

Jenner P, Dexter DT, Sian J, Schapira AHV, Marsden CD
