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Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

The mechanism of action of these drugs is mainly achieved through antioxidant effects and the clearance of free radicals to achieve therapeutic effects

2008, pp

Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW (2000) Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

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