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The inactivation of FTH1 by homologous recombination in mice is embryonically lethal, whereas the knockout of FTL leads to embryonic lethality in approximately 50% of newborn mice ( In addition to cytosolic ferritin, the overexpression of mitochondrial ferritin (FTMT) in neuronal cells inhibits erastin-induced ferroptosis and increases the cellular labile iron pool ( Nuclear Receptor Coactivator 4 The degradation of ferritin can be completed by ferritinophagy, which is a type of selective autophagy mediated by nuclear receptor coactivator 4 (NCOA4)

Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22, 948, MY-5455, vinopectine and 1-methyl-3- isobutyl-8-(methylamino)xanthine

Trends Food Sci Technol 56:2138

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Chemical synthesis and biotransformation pathways of natural saponins are gradually discovered, which is helpful to enrich the structural diversity of saponins and develop promising compounds (Juang and Liang, 2020)