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The primary endpoint was time to first acute exacerbation, with secondary endpoints including acute exacerbation frequency, sputum and serum NSP activity levels, quality of life scores, and safety indicators

261,262 Following activation by hypoxia, recent evidence indicates that leukocytes exacerbate the inflammatory microenvironment

Schoenenberger collected blood from the cerebral veins of electrically sleep-induced rabbits and isolated a small peptide that, when infused into waking rabbits, appeared to increase slow-wave (delta) EEG activity