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We previously demonstrated that growth attenuation of rv1127c in propionate is rescued by the addition of either vitamin B 12 or acetate (Basu et al, 2018), data that phenocopies Mtb mutants lacking MCC enzymes (Lee et al, 2013), thus supporting an unexpected role for Rv1127c in the MCC (Borah et al, 2021)
While the efficacy of ICA-1s is well documented in-vitro , it has not been tested in-vivo 1,3,12
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It stops them from multiplying
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