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The safety of intravenous iron preparations: systematic review and meta-analysis

Abbreviations BPH: Benign prostatic hyperplasia LUTSs: Lower urinary tract symptoms OS: Oxidative stress DEGs: Differentially expressed genes MXRA5: Matrix-remodeling associated 5 CXCL13: C-X-C Motif Chemokine Ligand 13 BMP5: Bone morphogenetic protein 5 NELL2: Neural epidermal growth factor-like like 2 GPX3: Glutathione peroxidase 3 GSH: Glutathione ROS: Reactive oxygen species Cyto-C: Cytochrome c MMP: Mitochondrial membrane potential PCD: Programmed cell death MDA: Malondialdehyde H&E: Hematoxylin and eosin staining IHC: Immunohistochemical DMSO: Dimethyl sulfoxide T: Testosterone propionate RSL3: RAS-selective lethal 3 GPX4: Glutathione peroxidase 4 TRO: Troglitazone PPAR: Peroxisome proliferator-activated receptor Rapa: Rapamycin CQ: Chloroquine Nrf2: Nuclear factor erythroid 2-related factor 2 SOD2: Superoxide dismutase 2

Pain in the right upper quadrant of the abdomen, fatigue, pruritus, and jaundice may be associated with liver involvement

M., & Saha, S

Proteins were electrophoresed and transferred to membranes where the following primary antibodies were used: BMAL1 (1:500), CLOCK (1:200), CRY2 (1:500), NRF2 (1:500), GCLC (1:500), GS (1: 1000) or GR (1:500)