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Description
market was not because of a safety issue (Administration 2022)
All three of these factors work together
It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications
doi: 10.3390/ijms25189890 59
