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However, other studies have shown that TGF-1, through Smad3 activation, inhibits the expression of the glutamate-cystine antiporter system Xc-, enhancing lipid peroxidation levels in PLC/PRF/5, Huh7, Huh6, and Hep G2 cells marked by early TGF-1 genes, but not in cells marked by late TGF-1 genes [122]

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