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This was mediated by WD repeat-containing protein 24 (WDR24) expression in T cells, and as D-serine can also be present in the TME, it is also possibly involved in the silencing of T cells antitumor immune responses

Moreover, pharmacological interventions that target the HIF pathway and promote the stabilization of HIFs have been developed and tested in clinical trials to treat anaemia

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Timing: Any consistent time

Key regulatory axesincluding HIF-1, HHIP-PKM2, PTGES-AKT-HIF-1, and lactate/LDH-A (LDH5)-TGF-interact to collectively promote enhanced glycolysis and diminished oxidative metabolism, sustaining the pathological phenotype of the disease (8082)