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It plays crucial roles in oxygen binding and transport (globins), oxidative metabolism (cytochrome c oxidase, succinate dehydrogenase), xenobiotic detoxification (cytochrome P450), gas sensing (guanyl cyclases, nitic oxide synthase), and microRNA processing (DGCR8)

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Similarly, photoaging is caused by the formation of free radicals (both oxygen and nitrogen containing species) as a result of UVinduced inflammation, depletion of cellular antioxidants, and antioxidant enzymes, and DNA damage