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Besides its use as a local and topical anesthetic agent, lidocaine is used to treat ventricular arrhythmias, principally ventricular tachycardia and ventricular premature complexes in all species

Ni, H.-M

Moreover, NPC1 cell models have shown an inefficient activity of antioxidant enzymes and mitochondrial dysfunction, both of which can contribute to the pathogenesis of the disease [128]

During this transition, the placenta moves from a low oxygen/hypoxic environment to an oxygenated one

Together, these data show that BMS, which has already been used in multiple phase III clinical trials (NCT03661320, NCT03329846), is not only a potent IDO1 inhibitor, but also displays a significant off-target effect by inhibiting the Q-site of complex I and thereby the main entry of electrons into the respiratory chain