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Description
The G protein binding site is localized entirely within the PH domain, as the isolated domains from PLC 2 and PLC 3 were able to bind activated Rac1 with affinity comparable to the full-length enzymes ( K d approximately 25 M) (Snyder et al., 2003)
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10.1634/theoncologist.2009-0285 49 Yilmaz

Wei Y, Swenson L, Castro C, Derewenda U, Minor W, Arai H et al (1998) Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 resolution

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