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Characterization of internal validity threats to phase III clinical trials for chemotherapy-induced peripheral neuropathy management: a systematic review

eCollection 2025
F0 founders were crossed to C57BL/6 J mice to generate F1 progeny, which were used to establish the flox colony

Reticulocyte count is a test that measures the number of immature (young) red blood cells

(PMC) A separate metabolism-focused paper reviewing human trial history makes a similar point: early signals of weight loss were not consistently reproduced in later studies, particularly when intensive diet/exercise protocols were included
