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Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature

Encourage parents to choose activities that are acceptable and safe 5

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The BCAs new strategic position has made it clear that as an Association we are to do the very best for our patients, to treat them well, in all senses, and to help them heal and be healthy

Side Effects & Mitigation Because there is no completed human safety trial, the honest statement is that the human side-effect profile is not well characterised